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A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”

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Titanium dioxide production begins with the extraction of raw materials, typically ilmenite or rutile, from mines. In a white titanium dioxide factory, these minerals undergo a rigorous refining process that includes steps like sulfuric acid digestion, chloride process, or sulfate process, depending on the factory's technology and resources. The resulting titanium dioxide pigment is then purified, dried, and ground to achieve the desired particle size and quality.

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In conclusion, titanium dioxide is a versatile and widely used ingredient in the cosmetics industry. Its benefits include broad-spectrum sun protection, natural pigmentation, chemical stability, and non-irritating properties. While there are some safety concerns regarding its use, regulatory agencies have established guidelines to ensure its safe use in cosmetic products. As the demand for natural and safe cosmetic products continues to grow, the future outlook for TiO2 in the cosmetics industry looks promising.

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